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Risk of hypertension with multicystic kidney disease: a systematic review

H Narchi1

  • 1Paediatric Department, Sandwell General Hospital, West Bromwich B71 4HJ, UK. hassibnarchi@hotmail.com

Archives of Disease in Childhood
|May 6, 2005
PubMed

Insights

The risk of hypertension in children with unilateral multicystic kidney disease (MCKD) is low, occurring in approximately 5.4 per 1000 children. Further research is needed to establish optimal follow-up strategies for blood pressure monitoring.

Area of Science:

  • Pediatric Nephrology
  • Clinical Epidemiology

Background:

  • Children with multicystic kidney disease (MCKD) often receive conservative management.
  • There is a recognized, yet poorly defined, risk of hypertension in these children.
  • Current follow-up strategies may lack evidence-based justification.

Purpose of the Study:

  • To estimate the probability of developing hypertension in children with unilateral MCKD.
  • To inform evidence-based follow-up care for pediatric MCKD patients.

Main Methods:

  • Systematic review of published prospective and retrospective cohort studies.
  • Included children diagnosed with unilateral MCKD and managed conservatively.
  • Excluded studies with bilateral MCKD or nephrectomy (not for hypertension).

Main Results:

  • Six cases of hypertension observed in 1115 eligible children across 29 studies.
  • The estimated mean probability of developing hypertension was 5.4 per 1000 (95% CI: 1.9–11.7 per 1000).

Conclusions:

  • The risk of hypertension in pediatric unilateral MCKD is low.
  • Current data are insufficient to recommend specific blood pressure monitoring frequency or duration.
  • Large, long-term prospective cohort studies are required to guide follow-up protocols.
Abstract

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