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Human gliomas contain morphine.

Peter Olsen1, Mads Rasmussen, Wei Zhu

  • 1Department of Anaesthesia & Intensive Care, Aarhus University Hospital, Denmark.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|May 6, 2005
PubMed
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Morphine, an opiate alkaloid, was detected in human glioma tumors. This finding suggests morphine may play a role in tumor physiology and pathology.

Area of Science:

  • Biochemistry
  • Oncology
  • Neuroscience

Background:

  • Morphine has been identified in cancer cell lines.
  • The presence of endogenous morphine in actual tumors requires investigation.

Purpose of the Study:

  • To determine if human gliomas contain endogenous morphine.
  • To characterize the identified morphine in glioma tissues.

Main Methods:

  • Human glioma tissues were analyzed using high-performance liquid chromatography (HPLC).
  • Morphine levels were quantified using radioimmunoassay.
  • Identity was confirmed through Q-TOF-MS analysis.

Main Results:

  • Endogenous morphine was detected in all analyzed gliomas.

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  • Mass spectrometry confirmed the presence of morphine with a molecular mass of 286.14 Da.
  • Fragmentation analysis yielded mass spectra consistent with authentic morphine.

    • Conclusions:

    • Morphine is present in human gliomas.
    • This suggests a potential role for morphine in influencing tumor physiology and pathology.