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Related Experiment Videos

Glucose-oxidase based self-destructing polymeric vesicles.

Alessandro Napoli1, Mark J Boerakker, Nicola Tirelli

  • 1Institute for Biomedical Engineering and Department of Materials Science, Swiss Federal Institute of Technology (ETH) and University of Zurich, CH-8044 Zurich, Switzerland. alessandro.napoli@mat.ethz.ch

Langmuir : the ACS Journal of Surfaces and Colloids
|May 7, 2005
PubMed
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Synthetic polymersomes destabilize in response to oxidation, triggered by hydrogen peroxide. This glucose-oxidase system offers potential for smart nanocontainers in sensing and drug delivery applications.

Area of Science:

  • Polymer chemistry
  • Nanotechnology
  • Biomaterials

Background:

  • Designed oxidation-responsive vesicles from synthetic amphiphilic block copolymers (polymersomes) of ethylene glycol and propylene sulfide.
  • Thioethers in the hydrophobic poly(propylene sulfide) block convert to hydrophilic sulfoxides/sulfones in oxidative environments, inducing polymersome solubilization.

Discussion:

  • Explored generating an oxidative environment and inducing polymersome destabilization using the glucose-oxidase (GOx)/glucose/oxygen system.
  • Investigated GOx encapsulation within polymersomes, its stability, and activity.
  • Studied glucose-triggered polymersome destabilization.

Key Insights:

  • Polymersomes can be controllably destabilized by an internally generated oxidative environment.

Related Experiment Videos

  • The GOx/glucose/oxygen system effectively triggers polymersome disassembly.
  • Encapsulated GOx maintains stability and activity within the polymersomes.

    • Outlook:

    • Stimulus-responsive polymersomes show promise as nanocontainers for sensing devices.
    • Potential applications in targeted drug delivery systems.