Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Declining cell-mediated immunity and increased chronic disease burden.

Asif Rafi1, William Crawford, William Klaustermeyer

  • 1Veterans Affairs Greater Los Angeles Healthcare System, Division of Allergy and Immunology, The David Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA. asifrafi1@yahoo.com

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|May 7, 2005
PubMed
Summary

Chronic disease burden, not age, significantly impacts cell-mediated immunity. Declining immune response is linked to higher disease burden, suggesting disease management is key for immune health in the elderly.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cohort vs case-control design for transformer-based prediction of asthma exacerbations in mild asthma.

NPJ digital medicine·2026
Same author

Statins associate with reduced asthma exacerbation risk in Black and obese patients with mild asthma.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2025
Same author

Identifying Asthma-Related Symptoms From Electronic Health Records Using a Hybrid Natural Language Processing Approach Within a Large Integrated Health Care System: Retrospective Study.

JMIR AI·2025
Same author

Symptoms of Asthma Extracted Through Natural Language Processing and Their Associations With Acute Asthma Exacerbation in Adults With Mild Asthma.

The journal of allergy and clinical immunology. In practice·2025
Same author

Risk Factors for Acute Asthma Exacerbations in Adults With Mild Asthma.

The journal of allergy and clinical immunology. In practice·2024
Same author

Population-Based Incidence, Severity, and Risk Factors Associated with Treated Acute-Onset COVID-19 mRNA Vaccination-Associated Hypersensitivity Reactions.

The journal of allergy and clinical immunology. In practice·2021

Area of Science:

  • Immunology
  • Gerontology
  • Chronic Disease Research

Background:

  • Conflicting study results on age-related immune decline may stem from chronic disease effects.
  • Cell-mediated immunity is crucial for immune defense and can be affected by various factors.

Purpose of the Study:

  • To test if chronic disease burden, rather than chronological age, is the primary driver of reduced cell-mediated immunity.
  • Investigate the relationship between disease severity and immune function in elderly individuals.

Main Methods:

  • Assessed delayed-type hypersensitivity (DTH) responses to Candida and tetanus antigens in 58 elderly participants.
  • Quantified disease burden using the Cumulative Illness Rating Scale (CIRS), comparing DTH responses across age groups and CIRS scores.
  • Measured total serum IgE levels and stratified them by age and CIRS score.

Related Experiment Videos

Main Results:

  • Candida DTH responsiveness declined significantly with increasing CIRS scores (higher disease burden).
  • No progressive decline in DTH responses was observed with advancing chronological age.
  • Total serum IgE levels increased with age, but showed no correlation with disease burden (CIRS score).

Conclusions:

  • Increased chronic disease burden is inversely associated with cell-mediated immune response (DTH).
  • Chronological age was not a predictor of diminished DTH response in this cohort.
  • Chronic disease burden does not correlate with total serum IgE levels.