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Updated: Aug 18, 2026

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Published on: March 2, 2020
[Synthesis and antibacterial activity of ciprofloxacin derivatives]
Fa-qing Ye1, You-mei Ding, Li Chen
1Department of Medicinal Chemistry, Wenzhou Medical College, Wenzhou 325035, China. yfq@wzmc.net
Aim:
To study the synthesis and antibacterial activity of ciprofloxacin derivatives.
Methods:
Ciprofloxacin derivatives were synthesized primarily from 2-methyl-5-nitroimidazol and ciprofloxacin through nucleophilic substitution. The antibacterial activity of the synthesized compounds were tested.
Results:
Nine new compounds were synthesized. The structure of the title compounds were confirmed by 1H NMR, MS and element analysis.
Conclusion:
Compounds II, IVC and IVD showed appreciable antibacterial activity, and were worth further studying.
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