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Updated: Aug 18, 2026

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
Published on: March 28, 2013
[Design, synthesis and insulin-sensitizing activity of some peroxisome proliferator-activated gamma agonists]
Chao-bin Zhong1, Xue-jun Zhu, Zhong-rong Liu
1R&D Department, Chengdu Di'ao Pharmaceutical Group Co., LTD, Chengdu 610041, China.
Aim:
To find new peroxisome proliferator-activated y agonists with high activity and low toxicity.
Methods:
Based on JTT-501 and JTT-20993, new isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds were designed and synthesized. Their insulin-sensitizing activities were evaluated.
Results:
Eight new compounds were obtained. The structures of synthesized compounds were characterized by NMR, MS and IR. Four compounds (1A-4A) showed insulin-sensitizing activities.
Conclusion:
Compounds (1A and 3A) showed excellent insulin-sensitizing activities and should be worth further investigation.
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