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[Metabolic pathways of dipfluzine in rats]
Hui-chen Liu1, Yu-min Du, Yong-li Wang
1Department of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China.
Aim:
To investigate the metabolic pathways of dipfluzine in rats.
Methods:
After an oral dose of dipfluzine (80 mg x kg(-1)) to rats, urine was collected for 12 h. The metabolites of dipfluzine in urine were chromatographed and identified by LC/DAD/MS methods.
Results:
In the rat urine, there were 1-(4-fluorophenyl)-4-piperazinylbutanone and its glucuronide, 4-hydroxybenzophenone and its glucuronide, 4-fluoro-gamma-hydroxybenzenebutanoic acid and its glucuronide and sulfate, diphenylmethanol and its glucuronide, dipfluzine, and benzophenone.
Conclusion:
In rats, dipfluzine was mainly metabolized in the pathways of N-desalkylation at 1- and 4-positions of piperazine ring. Some of metabolites were further conjugated with glucuronic acid and/or sulfuric acid.
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