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[Preparation and characterization of indomethacin/poly(N-isopropylacrylamide)-beta-cyclodextrin complex with
1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China.
Aim:
To synthesize poly(N-isopropylacrylamide)/cyclodextrin conjugate (PNIPA-beta-CD) as thermosensitive drug carrier, incorporate indomethacin into the conjugate and evaluate the drug release from the carrier in vitro.
Methods:
PNIPA-beta-CD was synthesized by introducing carboxyl terminated PNIPA into the primary hydroxy group of beta-CD. The obtained conjugate was characterized by FTIR, 1H NMR and DSC. The indomethacin/PNIPA-beta-CD complex was prepared by lyophilization. In vitro drug release from the complex was carried out at 25 degrees C and 37 degrees C respectively.
Results:
Thermosensitive PNIPA-beta-CD was synthesized successfully. The LCST is 35 degrees C, as measured by turbidity method. The drug release from indomethacin/PNIPA-beta-CD complex was slower at 37 degrees C than that at 25 degrees C.
Conclusion:
Thermosensitive PNIPA-beta-CD with molecular inclusion capacity is a potential carrier for drug sustained release.
