Synthesis of cationic water-soluble light-harvesting dendrimers
Shu Wang1, Janice W Hong, Guillermo C Bazan
1Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. China.
Organic Letters
|May 7, 2005
Abstract:
Four generations of phenylenefluorene (1F)- and phenylenebis(fluorene) (2F)-terminated polyamidoamine (PAMAM) dendrimers were synthesized by coupling activated esters with commercially available PAMAM precursors. Treatment of Boc-terminated pendant groups on the optically active units with 3 M HCl in dioxane yields cationic water-soluble dendrimers. Fluorescence resonance energy transfer (FRET) experiments with the cationic dendrimers as the donor and double stranded DNA containing a fluorescein label as the acceptor reveal cooperative optical behavior.
