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Updated: Aug 18, 2026

Saccharomyces cerevisiae Exponential Growth Kinetics in Batch Culture to Analyze Respiratory and Fermentative Metabolism
Published on: September 30, 2018
Adaptation of Saccharomyces cerevisiae to high hydrostatic pressure causing growth inhibition
Hitoshi Iwahashi1, Mine Odani, Emi Ishidou
1Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan. hitoshi.iwahashi@aist.go.jp
Abstract:
Genome-wide mRNA expression profiles of Saccharomyces cerevisiae growing under hydrostatic pressure were characterized. We selected a hydrostatic pressure of 30 MPa at 25 degrees C because yeast cells were able to grow under these conditions, while cell size and complexity were increased after decompression. Functional characterization of pressure-induced genes suggests that genes involved in protein metabolism and membrane metabolism were induced. The response to 30 MPa was significantly different from that observed under lethal conditions because protein degradation was not activated under 30 MPa pressure. Strongly induced genes those that contribute to membrane metabolism and which are also induced by detergents, oils, and membrane stabilizers.
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