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Updated: Nov 24, 2025
Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay
Published on: June 7, 2020
Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones
Robert E McDevitt1, Michael S Malamas, Eric S Manas
1Department of Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543-8000, USA. mcdevib@wyeth.com
Abstract:
The syntheses of a series of 2-arylindene-1-ones as potent ligands of ERbeta and ERalpha are described. Several compounds exhibited high potency and moderate selectivity for the ERbeta receptor. X-ray and modeling studies were used to understand ligand binding orientation and observed affinity.
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