Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonsegmental vitiligo: decrease of the CD45RA+ T-cell subset and evidence for peripheral T-cell activation.

M B Abdel-Naser1, W D Ludwig, H Gollnick

  • 1Department of Dermatology, University Medical Center Steglitz, Free University of Berlin, Germany.

International Journal of Dermatology
|May 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pioneers in Dermatology and Venereology: an interview with Prof. Constantin Orfanos.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

[Not Available].

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2016
Same author

From Hippocrates to modern medicine.

Journal of the European Academy of Dermatology and Venereology : JEADV·2007
Same author

Downregulation of cell cycle modulators p21, p27, p53, Rb and proapoptotic Bcl-2-related proteins Bax and Bak in cutaneous melanoma is associated with worse patient prognosis: preliminary findings.

Journal of cutaneous pathology·2007
Same author

HIV - associated and non - HIV associated types of Kaposi's sarcoma in an African population in Tanzania. Status of immune suppression and HHV-8 seroprevalence.

European journal of dermatology : EJD·2007
Same author

Antigen mimicry, epitope spreading and the pathogenesis of pemphigus.

Tissue antigens·2006
Same journal

SENTINOLD and the Challenge of Meaningful Risk Prediction in Melanoma.

International journal of dermatology·2026
Same journal

The "Stamp-n-Tack" Technique: An Ink-Guided Precision Method for Anchoring Tissue After Releasing Facial Retaining Ligaments in Large Facial Flap Reconstruction.

International journal of dermatology·2026
Same journal

Counterfactual Dermatology With Generative Models.

International journal of dermatology·2026
Same journal

Correlation of Clinical and Histopathological Features With Anti-Desmoglein Antibody Profile in Pemphigus Patients.

International journal of dermatology·2026
Same journal

Paracetamol-Induced Generalized Bullous Fixed Drug Eruption With Positive Anti-BP230 Antibody and Confirmed With Oral Provocation Test in a Child: A Case Report From the Philippines.

International journal of dermatology·2026
Same journal

Clinicopathological Challenge: A Painful Violaceous Reticulated Patch.

International journal of dermatology·2026
See all related articles

Peripheral T-lymphocyte analysis in nonsegmental vitiligo reveals decreased CD45RA+ cells and increased HLA-DR+ cells, suggesting autoimmune involvement and T-cell dysregulation in this skin condition.

Area of Science:

  • Immunology
  • Dermatology
  • Autoimmune Diseases

Background:

  • Nonsegmental vitiligo is a chronic autoimmune condition characterized by depigmentation of the skin.
  • The pathogenesis of vitiligo is complex and involves immune system dysregulation.
  • T-lymphocytes play a crucial role in immune responses and are implicated in autoimmune diseases.

Purpose of the Study:

  • To investigate the T-lymphocyte subsets and activation markers in peripheral blood of patients with nonsegmental vitiligo.
  • To identify potential immunological alterations contributing to the pathogenesis of nonsegmental vitiligo.

Main Methods:

  • Peripheral blood T-lymphocytes from 16 nonsegmental vitiligo patients and matched controls were analyzed.
  • Monoclonal antibodies were used to identify T-cell receptor (TCR) alpha/beta, TCR gamma/delta, CD3, CD4, CD8, CD45RA, CD45RO, CD11b, CD11c, CD16, CD56, CD25, CD54, and HLA-DR antigens.

Related Experiment Videos

  • Flow cytometry was employed for cell subset identification and quantification.

    • Main Results:

    • A significant decrease in the CD45RA+ T-lymphocyte subset was observed in vitiligo patients compared to controls (P < 0.03).
    • A significant increase in circulating HLA-DR+ cells, indicating T-cell activation, was found in vitiligo patients (P < 0.02).
    • No other significant alterations in the analyzed T-lymphocyte markers were detected.

    Conclusions:

    • The findings suggest the involvement of autoimmune phenomena in the pathogenesis of nonsegmental vitiligo.
    • Increased HLA-DR expression points to the presence of activated peripheral T-cells in vitiligo patients.
    • These results provide further evidence for T-cell dysregulation in nonsegmental vitiligo.