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Related Experiment Videos

Acute disseminated encephalomyelitis--a case series.

Sonia Madan1, S Aneja, R P Tripathi

  • 1Department of Pediatrics, Lady Hardinge Medical College; New Delhi, India. Sachin@ndf.vsnl.net.in

Indian Pediatrics
|May 7, 2005
PubMed
Summary

Acute disseminated encephalomyelitis (ADEM) is a rare central nervous system inflammatory disease. This study describes seven cases, highlighting varied presentations and outcomes, with MRI proving crucial for diagnosis.

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Area of Science:

  • Neurology
  • Neuroimmunology
  • Radiology

Background:

  • Acute disseminated encephalomyelitis (ADEM) is an uncommon inflammatory demyelinating disease.
  • It primarily affects the central nervous system's white matter.

Purpose of the Study:

  • To describe a series of seven cases of ADEM observed over one year.
  • To analyze the clinical presentations, radiological findings, and patient outcomes.

Main Methods:

  • Retrospective case series of seven patients diagnosed with ADEM.
  • Clinical data collection including neurological deficits and sensorium alterations.
  • Radiological assessment using CT and MRI scans.

Main Results:

  • Patients presented with acute onset focal neurological deficits, altered sensorium, or ataxia.

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  • CT scans showed non-specific hypodensities or were normal.
  • MRI revealed characteristic radiological changes indicative of ADEM.
  • Outcomes included complete recovery (3 patients), death (1 patient), and sequelae (3 patients).

    • Conclusions:

    • ADEM presents with diverse neurological symptoms.
    • MRI is essential for diagnosing ADEM, often showing characteristic changes.
    • Patient outcomes vary significantly, with a notable proportion experiencing sequelae or mortality.