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Published on: December 15, 2011

Selective IgA deficiency in children with recurrent parotitis of childhood

Tamas Fazekas1, Peter Wiesbauer, Brigitte Schroth

  • 1St. Anna Children's Hospital, Vienna, Austria.

The Pediatric Infectious Disease Journal
|May 7, 2005
PubMed

Insights

Recurrent parotitis of childhood, a relapsing inflammatory disorder of the parotid gland, affects 28% of juvenile parotitis cases. A significant association was found with selective IgA deficiency.

Area of Science:

  • Pediatric immunology
  • Otolaryngology
  • Inflammatory disorders

Background:

  • Recurrent parotitis of childhood is a rare, relapsing inflammatory condition affecting the parotid gland.
  • It can lead to significant morbidity in children.
  • Juvenile parotitis is the idiopathic form of this condition.

Purpose of the Study:

  • To define the prevalence and characteristics of recurrent parotitis of childhood.
  • To investigate potential underlying conditions, specifically selective IgA deficiency, in affected children.

Main Methods:

  • Retrospective chart review of patients diagnosed with inflammatory parotid diseases between 1992 and 2002.
  • Analysis of patient demographics, clinical presentation, and laboratory findings.
  • Comparison of IgA deficiency prevalence with healthy populations.

Main Results:

  • Out of 91 patients with juvenile parotitis, 23 (28%) had the relapsing form.
  • The median number of recurrent episodes was 5 (range, 2-20).
  • Selective IgA deficiency was identified in 5 patients (22%), a significantly higher prevalence than in the general population (0.3%; P < 0.001).

Conclusions:

  • Recurrent parotitis of childhood is a distinct entity within juvenile parotitis.
  • Selective IgA deficiency is notably more prevalent in children with recurrent parotitis.
  • Further research is warranted to explore the immunologic underpinnings of this condition.

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