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[Study on high mobility group-1 protein in patients with multiple trauma]
Jun Fei1, Hong-jun Yu, Jian Zhou
1Department of Trauma, Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China.
Summary
Serum high mobility group-1 (HMG-1) protein levels increase in multiple trauma patients and correlate with injury severity. Serial HMG-1 measurements can help detect clinical infection and predict multiple organ dysfunction syndrome (MODS) onset.
Area of Science:
- Biochemistry
- Trauma Medicine
- Critical Care
Context:
- Multiple trauma patients exhibit elevated serum high mobility group-1 (HMG-1) levels compared to healthy controls.
- HMG-1 levels are significantly higher in patients who develop organ dysfunction.
Purpose:
- To investigate the dynamic changes in serum HMG-1 protein following multiple trauma.
- To assess the correlation between HMG-1 levels, trauma severity (ISS, APACHE II), and the development of multiple organ dysfunction syndrome (MODS).
Summary:
- Serum HMG-1 levels were measured on days 1, 3, and 7 post-trauma in 33 patients.
- A positive correlation was observed between HMG-1 levels and the APACHE II score (r=0.495, P=0.016).
- Elevated HMG-1 and APACHE II scores were noted in patients with organ dysfunction, though SIRS scores did not significantly differ.
Impact:
- Serum HMG-1 serves as a valuable biomarker for trauma severity.
- Serial HMG-1 monitoring can aid in the early detection of clinical infections.
- HMG-1 shows potential as an early warning indicator for the onset of MODS.