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Antibacterial potential from Indian Suregada angustifolia
M Venkatesan1, M B Viswanathan, N Ramesh
1Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi 627 412, Tamil Nadu, India.
Journal of Ethnopharmacology
|May 10, 2005
Summary
Phytochemical analysis of Suregada angustifolia leaves revealed antibacterial compounds. Methanol and hexane extracts showed significant activity against Staphylococcus aureus, a common cause of skin infections.
Area of Science:
- Phytochemistry
- Pharmacology
- Microbiology
Background:
- The Indian plant Suregada angustifolia (Euphorbiaceae) is a source of various phytochemicals.
- Understanding the antibacterial potential of medicinal plants is crucial for developing new antimicrobial agents.
Purpose of the Study:
- To isolate and identify compounds from Suregada angustifolia leaves.
- To evaluate the antibacterial activity of leaf extracts against human pathogenic bacteria.
Main Methods:
- Phytochemical analysis was performed to isolate known compounds.
- Aqueous and solvent (methanol, hexane, chloroform) leaf extracts were prepared.
- Agar well-diffusion method was used to test antibacterial activity against 12 bacterial strains.
Main Results:
- Six known compounds were isolated: friedelin, epi-friedelinol, n-octacosanol, alpha-amyrin, beta-sitosterol, and beta-sitosterol-3-beta-D-glucopyranoside.
- Aqueous extracts showed no antibacterial activity.
- Solvent extracts exhibited antibacterial activity in the order: methanol > hexane > chloroform.
- Methanol and hexane extracts demonstrated maximum activity against Staphylococcus aureus.
- Hexane and chloroform extracts showed moderate activity against Vibrio vulnificus and Vibrio cholerae, respectively.
Conclusions:
- Suregada angustifolia leaf extracts possess significant antibacterial properties, particularly against Staphylococcus aureus.
- The study highlights the potential of Suregada angustifolia as a source for novel antibacterial compounds.