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Updated: Aug 18, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
P L Chong1, K Salhiyyah, P D F Dodd
1Sheffield Vascular Institute, Northern General Hospital, Sheffield, South Yorkshire S5 7AU, UK.
Insights
A significant proportion of patients with high-grade symptomatic carotid disease are unsuitable for carotid artery angioplasty and stenting (CAS) due to anatomical limitations. This finding is crucial for guiding treatment decisions in cerebrovascular disease management.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Neurology
Background:
- Carotid artery angioplasty and stenting (CAS) is an alternative to surgery for high-grade symptomatic carotid disease.
- Patient suitability for CAS versus surgical intervention requires careful evaluation.
Purpose of the Study:
- To determine the proportion of patients suitable for CAS versus surgery.
- To analyze reasons for unsuitability for carotid stenting.
Main Methods:
- Prospective observational study over 18 months.
- Analysis of management decisions and reasons for stenting unsuitability.
- Inclusion of all patients considered for carotid artery intervention.
Main Results:
- 224 patients had complete records; 177 required intervention.
- 113 patients were suitable for stenting, while 64 were not.
- Carotid tortuosity and proximal disease were the primary reasons (70%) for stenting unsuitability.
Conclusions:
- 36% of patients requiring intervention were unsuitable for stenting.
- Carotid anatomy presents significant technical challenges for stenting.
- Treatment decisions should consider anatomical limitations alongside clinical trial data.
Objective:
Carotid artery angioplasty and stenting (CAS) has been proposed as an alternative to surgery for patients with high-grade symptomatic carotid disease. The purpose of this study was to determine the proportion of patients that were suitable for each type of intervention and to analyse the reasons that precluded stenting.
Materials And Methods:
This was a prospective observational study. All patients considered for intervention for carotid artery disease during an 18-month period were analysed. The management decision was recorded, as were the reasons for unsuitability for stenting.
Results:
Two hundred and sixty-eight patients' data were analysed, 224 had complete records. Forty-seven patients did not require intervention and received best medical treatment alone. One hundred and seventy-seven patients required intervention, 113 were suitable for stenting and 64 were not. In 51 patients stenting was preferred. Sixty-two patients were suitable for either stent or surgery. Sixty-four patients were unsuitable for stenting. Carotid tortuosity and proximal disease accounted for 70% of this group.
Conclusions:
Current enthusiasm for carotid stenting might well be supported by the results of ongoing randomised-controlled clinical trials. However, this study highlights a significant proportion (64/177; 36%) of our patients is presently unsuitable for stenting. The common technical difficulties and limitations of stenting encountered in our unit are related predominantly to carotid anatomy.
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