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Updated: Aug 18, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
Brain perfusion differences between Parkinson's disease and multiple system atrophy with predominant parkinsonian
Hideaki Matsui1, Fukashi Udaka, Takafumi Miyoshi
1Department of Neurology, Sumitomo Hospital, 5-3-20 Nakanoshima, Osaka 530-0005, Japan. matsui-hideaki@sumitomo-hp.or.jp
Background:
The patterns of regional cerebral blood flow in Parkinson's disease and multiple system atrophy remain inconsistent.
Objectives:
To compare brain perfusion images of 123I-IMP SPECT between Parkinson's disease, multiple system atrophy with predominant parkinsonian features (MSA-P) and controls.
Methods:
Eighty-two patients with Parkinson's disease, 10 patients with MSA-P and 14 controls were studied. We performed 3D-SSP and volume of interest analysis using 123I-IMP scintigraphy.
Results:
Occipital perfusion of MSA-P increased compared to that of Parkinson's disease and perfusion in the cerebellum and primary sensorimotor cortex of Parkinson's disease increased compared to that of MSA-P. Perfusion in the putamen of MSA-P decreased compared to that of Parkinson's disease.
Conclusion:
Our study demonstrated perfusion differences in 123I-IMP SPECT between the two diseases.
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