Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Altering metabolism.

Clifford T Pereira1, Kevin D Murphy, David N Herndon

  • 1Shriners Hospitals for Children, Galveston, Texas 77550, USA.

The Journal of Burn Care & Rehabilitation
|May 10, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defining the Zone of Acute Peripheral Nerve Injury Using Fluorescence Lifetime Imaging in a Crush Injury Sheep Model.

The Journal of hand surgery·2025
Same author

Exploring the role of peripheral nerves in trauma-induced heterotopic ossification.

JBMR plus·2024
Same author

Molecular Basis of Surgical Coaptation Techniques in Peripheral Nerve Injuries.

Journal of clinical medicine·2023
Same author

Sensorimotor Outcomes of Upper Extremity End-to-Side Nerve Transfers: A Meta-analysis.

Annals of plastic surgery·2022
Same author

Substance Addiction and the Hand Surgery Patient: A Comprehensive Review.

The Journal of hand surgery·2021
Same author

Neurotization of the Nipple-Areola Complex during Implant-Based Reconstruction: Evaluation of Early Sensation Recovery.

Plastic and reconstructive surgery·2021
Same journal

Efficacy of a short-term, intensive social skills training program for burned adolescents.

The Journal of burn care & rehabilitation·2005
Same journal

Celebrating progress in psychosocial rehabilitation: empirically validating the efficacy of social skills training and body image assessment for burn survivors.

The Journal of burn care & rehabilitation·2005
Same journal

Axillary burns: extended grafting and early splinting prevents contractures.

The Journal of burn care & rehabilitation·2005
Same journal

Impact of an inpatient rehabilitation facility on functional outcome and length of stay of burn survivors.

The Journal of burn care & rehabilitation·2005
Same journal

The Functional Independence Measure (FIM) and functional outcomes after a new approach to axillary burns.

The Journal of burn care & rehabilitation·2005
Same journal

Patients with epilepsy: a high-risk population prone to severe burns as a consequence of seizures while showering.

The Journal of burn care & rehabilitation·2005
See all related articles

Severe burns trigger a prolonged hypermetabolic response, impacting healing and recovery. This review explores nonpharmacologic and pharmacologic strategies to manage postburn metabolism and improve outcomes for burn survivors.

Area of Science:

  • Metabolic response to injury
  • Burn rehabilitation

Background:

  • Severe burns induce a hypermetabolic state, persisting up to a year post-injury.
  • This response contributes to mortality, morbidity, impaired healing, infections, and reduced quality of life.
  • Effective management of postburn hypermetabolism is crucial for patient recovery and reintegration.

Purpose of the Study:

  • To review pharmacologic and nonpharmacologic strategies for reversing the catabolic effects of thermal injury.
  • To discuss modulators of postburn metabolism.

Main Methods:

  • Review of existing literature on burn hypermetabolism.
  • Discussion of nonpharmacologic interventions: wound care, sepsis management, environmental control, nutrition, and exercise.
  • Analysis of pharmacologic interventions: growth hormone, insulin, oxandrolone, and propranolol.

Related Experiment Videos

Main Results:

  • Nonpharmacologic strategies include early wound closure, sepsis control, thermal neutrality, optimized nutrition, and exercise.
  • Pharmacologic options include recombinant human growth hormone, insulin infusion, oxandrolone, and propranolol.
  • These interventions aim to mitigate the catabolic state and its consequences.

Conclusions:

  • Both nonpharmacologic and pharmacologic approaches are vital for managing postburn hypermetabolism.
  • Targeting metabolic pathways can improve wound healing, reduce complications, and enhance long-term recovery for burn survivors.