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Related Experiment Videos

Blood component collection by apheresis.

Edwin A Burgstaler1

  • 1Division of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. burgstaler.edwin@mayo.edu

Journal of Clinical Apheresis
|May 10, 2005
PubMed
Summary
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Automated apheresis component collection offers controlled blood product volumes and efficient donor utilization. This technology is rapidly expanding for optimal blood component provision, despite equipment costs and specialized operator needs.

Area of Science:

  • Blood Collection Technology
  • Transfusion Medicine
  • Hematology

Background:

  • Apheresis component collection is a growing field within blood collection.
  • Various instruments with different capabilities are available for apheresis.
  • This review covers equipment for granulocyte, platelet, red blood cell, and plasma collection.

Purpose of the Study:

  • To review available equipment for granulocyte and apheresis component collection.
  • To discuss indications for the use of apheresis component collection.
  • To highlight advancements in apheresis technology and yields.

Main Methods:

  • Review of available apheresis instruments in the United States.
  • Discussion of factors influencing component yields (e.g., G-CSF, hetastarch).

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  • Analysis of reported collection rates and efficiencies.

    • Main Results:

    • Specific apheresis devices for granulocyte, platelet, RBC, and plasma collection are identified.
    • Granulocyte yields significantly increase with G-CSF and dexamethasone stimulation.
    • Reported platelet collection rates range from 0.045-0.115 x 10(11) plt/min with 46-85.7% efficiency.

    Conclusions:

    • Automated apheresis offers advantages like controlled component doses, efficient donor use, and improved quality control.
    • Disadvantages include high equipment costs, need for trained operators, and lower volume capacity than whole blood donation.
    • Apheresis component collection is rapidly expanding to efficiently provide optimal blood components.