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Recurrent central neurocytomas.

Alexander Bertalanffy1, Karl Roessler, Oskar Koperek

  • 1Neurosurgical Department, Medical University of Vienna, Vienna, Austria. alexander.bertalanffy@univie.ac.at

Cancer
|May 10, 2005
PubMed
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Central neurocytomas (CNs) may recur more often than previously thought, even after complete surgical removal. Long-term, periodic neuroradiologic follow-up is essential for all patients diagnosed with CNs.

Area of Science:

  • Neuro-oncology
  • Neurosurgery
  • Pathology

Background:

  • Central neurocytomas (CNs) were first described in 1982 as benign tumors.
  • Historically, CNs have been associated with a favorable prognosis and successful surgical outcomes.
  • This study aimed to re-evaluate recurrence rates in CNs over extended follow-up periods.

Purpose of the Study:

  • To investigate the long-term disease recurrence frequency of Central neurocytomas (CNs).
  • To assess the efficacy of surgical resection and subsequent treatments for recurrent CNs.
  • To determine if clinicoradiologic, histologic, or immunohistochemical features predict recurrence.

Main Methods:

  • Retrospective analysis of medical records for 14 patients with CNs (ages 16-43) treated between 1985-2003.

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  • Evaluation of clinicoradiologic findings, histologic, and immunohistochemical features.
  • Assessment of recurrence, progression, and survival outcomes.

    • Main Results:

    • 14 patients underwent surgical resection; 2 (14%) died postoperatively, and 1 (7%) had malignant transformation.
    • Disease recurrence occurred in 5 patients (38%) after complete resection, with a median time of 67 months post-surgery.
    • Histologic and immunohistochemical markers, including MIB-1 proliferation index, did not reliably predict recurrence.
    • Radiation therapy (gamma knife, interstitial irradiation) was effective for recurrent disease.

    Conclusions:

    • Central neurocytomas exhibit a higher recurrence rate than previously reported, even after complete surgical resection.
    • Periodic neuroradiologic follow-up is crucial for all patients with CNs, regardless of initial resection status.
    • Long-term surveillance is necessary to detect late recurrences.