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Adenovirus-mediated Genetic Removal of Signaling Molecules in Cultured Primary Mouse Embryonic Fibroblasts
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Published on: September 9, 2010

Targeting gene expression in the mouse somite: adenovirus-mediated gene delivery and whole embryo culture

Alice E Chen1, Chen-Ming Fan

  • 1Department of Embryology, Carnegie Institution of Washington, Baltimore, MD, USA.

Genesis (New York, N.Y. : 2000)
|May 10, 2005
PubMed

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.