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Related Experiment Videos

Eomesodermin is expressed in mouse oocytes and pre-implantation embryos.

Josie McConnell1, Linda Petrie, Fiona Stennard

  • 1Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom. josie.mcconnell@kcl.ac.uk

Molecular Reproduction and Development
|May 10, 2005
PubMed
Summary

Mouse Eomesodermin (mEomes) protein is present in early embryos, suggesting a role in preimplantation development and inner cell mass formation beyond its known function in trophoblast development.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • T-box genes encode transcription factors crucial for embryonic development.
  • Eomesodermin (Eomes) is a T-box gene vital for mesoderm formation in Xenopus.
  • Mouse Eomesodermin (mEomes) is known to function in trophoblast development.

Purpose of the Study:

  • To investigate the role of mEomes during early preimplantation embryonic development.
  • To determine if maternally encoded or early zygotic mEomes contributes to embryonic development.

Main Methods:

  • Analysis of mEomes mRNA and protein localization in oocytes and preimplantation embryos.
  • Immunofluorescence microscopy to visualize mEomes protein association with nuclear and spindle structures.

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Main Results:

  • mEomes mRNA is detected before blastocyst formation.
  • mEomes protein localizes to nuclear DNA in oocytes and preimplantation embryos.
  • mEomes protein associates with meiotic and mitotic spindles throughout early development.

Conclusions:

  • mEomes plays a significant role in early preimplantation development.
  • mEomes is involved in inner cell mass formation in addition to trophoblast development.