Related Experiment Video

Updated: Aug 18, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
12:22

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

[Reactivation of persistent herpes virus infection as a factor of endogenous uveitis in children]

G I Krichevskaia, V O Andzhelov, L A Katargina

    Vestnik Oftalmologii
    |May 11, 2005
    PubMed

    Insights

    Human herpes virus infections are common in children with endogenous uveitis. Reactivation, particularly of herpes simplex virus type 1, is frequent in those with weakened immunity, leading to severe uveitis.

    Area of Science:

    • Ophthalmology
    • Virology
    • Immunology

    Background:

    • Endogenous uveitis in children is a significant cause of vision impairment.
    • The role of viral and atypical infections in pediatric uveitis requires further elucidation.

    Purpose of the Study:

    • To investigate the prevalence of human herpes group virus, Mycoplasma, and Chlamydia infections in children with endogenous uveitis.
    • To identify associations between specific viral reactivations, immune status, and uveitis severity.

    Main Methods:

    • Retrospective analysis of 255 children (2 months to 15 years) diagnosed with endogenous uveitis.
    • Serological testing for past infections with human herpes group viruses, Mycoplasma, and Chlamydia.
    • Assessment of cell-mediated antiviral immunity.

    Main Results:

    • High prevalence (73-93%) of chronic human herpes group virus infections detected.
    • Herpes simplex virus type 1 reactivation was more common than other herpesviruses.
    • Cytomegalovirus reactivation was prevalent in mothers of infants with intrauterine uveitis.
    • Prolonged herpesvirus replication occurred in children with suppressed antiviral immunity.
    • Uveitis exhibited a severe clinical course with frequent relapses in these children.

    Conclusions:

    • Human herpes viruses are frequently implicated in pediatric endogenous uveitis.
    • Impaired cell-mediated antiviral immunity contributes to severe and recurrent uveitis in children.
    • Targeted antiviral therapies may be beneficial in managing herpesvirus-associated pediatric uveitis.

    More Related Videos

    Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK07:27

    Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

    Published on: December 18, 2012

    Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis10:33

    Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

    Published on: December 17, 2021

    Related Concept Videos

    Herpes01:28

    Herpes

    Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
    Chickenpox01:20

    Chickenpox

    Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
    Genital Herpes01:23

    Genital Herpes

    Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
    Cytomegalovirus Disease01:27

    Cytomegalovirus Disease

    Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
    Encephalitis ll: Pathophysiology01:26

    Encephalitis ll: Pathophysiology

    Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
    Encephalitis l: Introduction01:19

    Encephalitis l: Introduction

    Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...