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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
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[Cytoapheresis for IBD]

Akira Andoh1, Yoshihide Fujiyama

  • 1Department of Internal Medicine, Shiga University of Medical Science.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 11, 2005
PubMed

Ulcerative colitis (UC) is associated with chronic relapsing inflammation of the colon. Cytoapheresis is a therapeutic strategy of extracorporeal immunomodulation that has been used in several immunological disorders. In Japan, several open trials of cytoapheresis for UC patients accumulated encouraging results in bringing steroid-resistant patients into remission. In this paper, three types of cytoapheresis [leukocytapheresis (LCAP), granulocytapheresis (GCAP), and centrifugal leukocyte apheresis] are reviewed.

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