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Updated: Jul 18, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
Published on: July 18, 2014
[Primary cardiac angiosarcoma in the left atrium with adrenal metastasis; report of a case]
Fumiaki Kuwabara1, Y Hirate, T Sugiura
1Department of Cardiovascular Surgery, Nagoya Ekisaikai Hospital, Nagoya, Japan.
Insights
A rare primary cardiac angiosarcoma in the left atrium led to significant mitral valve issues. Despite initial resection, the cancer metastasized to the adrenal gland and recurred, ultimately causing heart failure.
Area of Science:
- Cardiology
- Oncology
- Pathology
Background:
- Primary cardiac angiosarcoma is a rare and aggressive malignancy.
- Left atrial angiosarcoma can significantly impact cardiac function, particularly the mitral valve.
Observation:
- A 61-year-old woman presented with a left atrial angiosarcoma involving the mitral valve, causing stenosis and regurgitation.
- Initial surgical resection improved mitral valve function postoperatively.
- Three months later, adrenal metastasis and left atrial recurrence were detected, alongside worsening mitral valve disease.
Findings:
- Cardiac angiosarcoma can metastasize to distant organs, such as the adrenal glands.
- Recurrence of angiosarcoma in the left atrium can lead to progressive mitral valve dysfunction.
- The patient succumbed to heart failure 185 days postoperatively due to disease progression.
Implications:
- Early detection and aggressive management are crucial for primary cardiac angiosarcoma.
- Metastatic spread and recurrence pose significant challenges in managing this condition.
- Multidisciplinary approaches are essential for optimizing patient outcomes in rare cardiac tumors.
Abstract:
We encountered a 61-year-old woman with primary cardiac angiosarcoma in the left atrium. On echocardiography, the tumor extended into the atrial septum and mitral valve, and mitral valve stenosis and regurgitation were significant. We resected the tumor protruding into left atrium, and affecting mitral valve. The surgical procedure was not radical, but on postoperative echocardiography, function of the mitral valve was improved. Three months later, elevation of her right diaphragma was observed on chest X-ray and a giant adrenal tumor was detected by magnetic resonance imaging. Tumor biopsy indicated that this tumor was adrenal metastasis from cardiac angiosarcoma. In addition, echocardiography showed the recurrence of angiosarcoma in the left atrium and the presence of mitral stenosis and regurgitation. She died of heart failure 185 days postoperatively.
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