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Updated: Aug 18, 2026

In vitro Measurements of Tracheal Constriction Using Mice
Published on: June 25, 2012
[Excretion of beta-elemene from rat respiratory tracts]
Kun Wang1, Zhi Li, Yu-ren Chen
1Department of Pharmacology, Dalian Medical University, Dalian 116027, China. liaoningdmu@yahoo.com.cn
Aim:
To investigate the excretion of beta-elemene from the respiratory tracts in male Spraque-Dawley rats.
Methods:
After a single administration of beta-elemene to rats at the dosage of 75 mg x kg(-1) (i.v. or i.p.), the exhaled gases were collected and concentrated at various time points. The residues were analyzed by gas chromatography.
Results:
A minor amount of unchanged beta-elemene was excreted via rat respiratory tracts after iv and ip administration of a single dose. The cumulative excretion were 1.41% and 0.51% respectively.
Conclusion:
The results demonstrated that unchanged beta-elemene excretes from rat respiratory tracts, but may not be the main elimination pathway in rats.
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