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Updated: Aug 18, 2026
Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
Experimental colitis does not increase the prevalence of ANKENT, a spontaneous joint disease in mice
J Capková1, R Stepánková, T Hudcovic
1Department of Biology and Biochemistry of Reproduction, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 142 20 Prague, Czechia. capkova@biomed.cas.cz
Abstract:
A possible relationship between intestinal inflammation and joint disease development was investigated. Clinical symptoms of colitis--diarrhea and rectal bleeding--were confirmed by findings of inflammatory processes in the colon in dextran sodium sulfate-treated mice and joint ankylosing enthesopathy (ANKENT) developed in 12.8 % mice with chronic colitis and 13.6 % mice in the control group. Consequently no significant difference in ANKENT frequency was found between mice with and without chronic colitis and the occurrence of ANKENT in both groups was typical for conventional conditions. ANKENT cannot be triggered solely a generalized inflammatory process in the gut.
