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Updated: Aug 18, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
[Schizophrenia--neurodevelopmental and neurodegenerative theory revisited]
Agata Szulc1, Beata Galińska, Andrzej Czernikiewicz
1Klinika Psychiatrii AM w Białymstoku.
Abstract:
The paper presents a critical review regarding the pathogenesis of schizophrenia. The neurodevelopmental theory which is now mostly recognized, needs some explanations, some elements of neurodegenerative theory are revisited. The developmental factors are confirmed as important in the pathogenesis of schizophrenia, but still it is unclear, how relatively subtle early damage causes so heavy thinking and emotional distortion like schizophrenia. There is also lack of evidence for neurodegeneration. Neuroimaging studies show the evidence for progression of brain abnormalities but at the same time there is no progression in neurocognitive disorders. Most likely late developmental disorders interfere with early brain damage, which leads to a neurocognitive disorder and clinical symptoms of schizophrenia.
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