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Updated: Aug 7, 2026

Recapitulation of an Ion Channel IV Curve Using Frequency Components
Published on: February 9, 2011
Gain control by concerted changes in I(A) and I(H) conductances
1Neurosciences Division, Biological Sciences, University of Manchester, Manchester, UK. denis.burdakov@man.ac.uk
Abstract:
Stability of intrinsic electrical activity and modulation of input-output gain are both important for neuronal information processing. It is therefore of interest to define biologically plausible parameters that allow these two features to coexist. Recent experiments indicate that in some biological neurons, the stability of spontaneous firing can arise from coregulated expression of the electrophysiologically opposing I(A) and I(H) currents. Here, I show that such balanced changes in I(A) and I(H) dramatically alter the slope of the relationship between the firing rate and driving current in a Hodgkin-Huxley-type model neuron. Concerted changes in I(A) and I(H) can thus control neuronal gain while preserving intrinsic activity.
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