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Acute myocardial infarction in young patients: nutritional status and biochemical factors
Anna Vittoria Mattioli1, Lorenzo Bonetti, Mauro Zennaro
1Department of Cardiology, University of Modena and Reggio Emilia, Via del pozzo, 71, 41100 Modena, Italy. mattioli.annavittoria@unimo.it
Insights
Younger patients with acute myocardial infarction (AMI) showed similar acute-phase reactants but higher levels of homocysteine, LDL, and triglycerides compared to older patients. Nutritional status also differed significantly between the age groups.
Area of Science:
- Cardiology
- Biochemistry
- Nutritional Science
Background:
- Acute myocardial infarction (AMI) affects individuals across all age groups.
- Understanding age-related differences in AMI patient profiles is crucial for tailored treatment strategies.
- Biochemical markers and nutritional status may play distinct roles in the pathophysiology of AMI in younger versus older populations.
Purpose of the Study:
- To compare nutritional status and biochemical factors, including C-reactive protein (CRP), serum amyloid A (SAA), serum iron (Fe), and fibrinogen, at admission between young (<40 years) and old (>60 years) male patients with AMI.
- To investigate differences in the increase of acute-phase reactants during hospitalization between young and old AMI patients.
- To examine disparities in dyslipidemic profiles between these two age groups.
Main Methods:
- The study included 40 young male AMI patients (mean age 36.7 years) and 40 older male AMI patients (mean age 66.3 years).
- CRP, SAA, Fe, and fibrinogen levels were measured at admission and daily for seven days.
- Nutritional status, homocysteine, LDL, and triglyceride levels were also assessed.
Main Results:
- Acute-phase reactants (CRP, SAA, Fe, fibrinogen) showed quantitatively similar levels between young and old AMI patients.
- Younger patients exhibited significantly higher levels of homocysteine, LDL, and triglycerides compared to older patients.
- Nutritional status was also found to be significantly different between the young and old AMI patient groups.
Conclusions:
- While acute-phase reactants do not significantly differentiate young from old AMI patients, other factors do.
- Younger AMI patients present with distinct biochemical profiles, including elevated homocysteine, LDL, and triglycerides, alongside differing nutritional status.
- These findings highlight the importance of considering age-specific risk factors and metabolic profiles in managing acute myocardial infarction.
Purpose:
The aim of this study was to establish whether nutritional status and biochemical factors, C-reactive protein (CRP), serum amyloid A (SAA) protein, serum iron (Fe) and fibrinogen at admission were different in patients with acute myocardial infarction (AMI) at a young age (<40 years) vs. those with AMI at an older age (>60 years). We also investigated whether during the stay in the hospital, the increase in acute-phase reactants was different in young vs. older subjects, and if dyslipidemic aspects were different between the two groups.
Methods:
The study population consisted of 40 patients, all males with a mean age of 36.7+/-1.16 years, admitted to our facility with AMI. The control group included 40 patients, all males, mean age of 66.3+/-4.24 years, with AMI. CRP, SAA, Fe and fibrinogen were determined at admission to the hospital and daily for 7 days in the two groups of patients.
Results:
In young patients the median value of the highest levels were 6.2 mg/l (range 0.7-27.30) for CRP, 13.22 mg/l (range 0.7-130) for SAA, 420 mg/dl (range 76-840) for fibrinogen and 49.1 gamma/ml (range 14-102) for Fe levels. In the older patients, the median value of the highest levels were 5.9 mg/l (range 0.6-28.30) for CRP, 12.12 mg/l (range 0.9-280) for SAA, 480 mg/dl (range 60-780) for fibrinogen and 47.1 gamma/ml (range 12-94) for Fe levels.
Conclusions:
In the present study, acute-phase reactants were quantitatively similar in young and old patients. On the contrary, nutritional status, homocysteine, LDL and triglycerides are significantly higher in young patients than in old patients.
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