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The predictive value of CKMB mass concentration in unstable angina pectoris: preliminary report
J Markenvard1, M Dellborg, R Jagenburg
1Department of Medicine, University of Göteborg, Sweden.
Insights
Elevated creatine kinase MB isoenzyme mass concentration in unstable angina patients indicates a higher risk of acute myocardial infarction or revascularization. This CKMB analysis can help identify high-risk individuals for better prognosis prediction.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Unstable angina pectoris (UAP) is a prevalent clinical issue.
- Current diagnostic methods based on symptoms lack the ability to identify high-risk patients.
- Holter monitoring and angiography are effective but time- and resource-intensive.
Purpose of the Study:
- To investigate the predictive value of creatine kinase MB isoenzyme mass concentration (CKMB) for prognosis in UAP patients.
- To determine if CKMB levels can aid in selecting high-risk UAP individuals.
Main Methods:
- A study involving 101 consecutive UAP patients.
- Blood samples collected thrice daily for 48 hours post-admission.
- Analysis of CKMB mass concentration in relation to patient outcomes.
Main Results:
- Patients with UAP and elevated CKMB (within normal range) showed a significantly higher risk of acute myocardial infarction.
- These patients also had a greater need for revascularization within 6 months.
- A comparison revealed a markedly increased risk compared to patients without elevated CKMB.
Conclusions:
- CKMB mass concentration is a valuable tool for predicting prognosis in UAP.
- CKMB analysis can assist in identifying high-risk UAP patients.
- Further extensive studies are recommended to confirm these findings.
Abstract:
Unstable angina pectoris is a common clinical problem, and the diagnosis is based on clinical symptoms. However, these symptoms cannot identify high-risk patients. Holter monitoring can identify patients at high risk, but analysis of a large number of patients is time- and resource-consuming, as is angiographic examination. We determined whether creatine kinase MB isoenzyme mass concentration could predict the prognosis for patients with unstable angina pectoris. A total of 101 consecutive patients were studied, and blood samples were collected three times a day for 48 h after admission. Patients with unstable angina and elevated CKMB (but still within the normal range) had a significantly higher risk of developing acute myocardial infarction or requiring revascularization during 6 months of follow-up than patients without elevated CKMB. We conclude that CKMB analysis is a valuable tool that may be of use in selecting high-risk patients with unstable angina pectoris. This finding needs to be confirmed by more extensive studies.