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Laparoscopic live donor nephrectomy has equivalent early and late renal function outcomes compared with open donor
Ithaar H Derweesh1, David A Goldfarb, Sidney C Abreu
1Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Urology
|May 11, 2005
Summary
Laparoscopic live donor nephrectomy (LDN) offers similar early and long-term kidney function and survival outcomes compared to open LDN. Radionuclide scans can further assess renal function recovery after LDN.
Area of Science:
- Nephrology
- Transplant Surgery
- Minimally Invasive Surgery
Background:
- Concerns exist regarding renal functional recovery after laparoscopic live donor nephrectomy (LDN).
- Radionuclide scans are proposed as an additional assessment tool for renal function post-LDN.
Purpose of the Study:
- To compare early functional recovery and long-term function of kidneys procured via laparoscopic versus open live donor nephrectomy (LDN).
- To evaluate the utility of radionuclide scans in assessing renal function after LDN.
Main Methods:
- Retrospective review of 101 laparoscopic and 35 open LDNs (1997-2001).
- Assessment of delayed renal function using serum creatinine, dialysis, and renography (time to peak/half peak activity).
- Long-term outcomes evaluated by serum creatinine, creatinine clearance, and patient/allograft survival up to 3 years.
Main Results:
- No significant differences in donor/recipient demographics, operative time, or blood loss between laparoscopic and open LDN.
- Identical early functional recovery parameters (renography, creatinine, dialysis) and long-term outcomes (survival, creatinine, rejection) were observed.
- Radionuclide scan parameters showed no significant differences between the groups.
Conclusions:
- Laparoscopic and open LDN techniques yield comparable early graft function and long-term renal function.
- Three-year patient and allograft survival rates are similar for both laparoscopic and open LDN procedures.