Related Experiment Video
Updated: Aug 18, 2026

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
Published on: April 24, 2020
[Circadian variations in intraocular pressure and their clinical implications]
1Service d'Ophtalmologie, CHU Sart Tilman B35, B-4000 Liège, Belgique. Pierre.Blaise@ulg.ac.be
Abstract:
Intraocular pressure follows a circadian rhythm like many of the body's parameters. These fluctuations in intraocular pressure were recently identified as a risk factor for visual field loss, in addition to intraocular pressure itself. Furthermore, the pressure curve seems to have a different profile in glaucomatous patients: the peak occurs later compared with normal subjects. Better knowledge of pressure fluctuations and their physiological mechanisms is essential for optimal management of glaucomatous patients not only to interpret the single ocular tension recordings, but also to use the available treatments rationally, both drugs and surgery. The authors review different studies that have contributed to the current knowledge on the circadian rhythm of intraocular pressure, aquous humor flow regulation, and the effects of topical hypotensive drugs on the pressure curve.
Related Concept Videos
Glaucoma: Overview
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Angle Closure Glaucoma: Treatment
Ophthalmic Drug Delivery Systems
Increased Intracranial Pressure l: Introduction