Related Experiment Video
Updated: Aug 18, 2026

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
Published on: May 21, 2020
[The mechanotransduction mechanism of how osteoblasts respond to mechanical stimulation]
Yuanliang Wang1, Liling Tang, Jianhua Wang
1Key Lab. of Biomechanics & Tissue Engineering under the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. wyl@cqu.edu.cn
Abstract:
The stress environment regulates the factors of growth, resorption and remolding in bone tissue. Mechanical stimulation at cell physical level affects the physiological activity of osteoblasts, including proliferation, ALP activity and osteocalcin production. Mechanotransduction is a procedure which transduces the biophysical force into biochemical responses. It is also the basis of many physiological functions. The early response genes (c-fos, c-jun), the second message systems (Ca2+, NO, cAMP) and the mechano-sensitive cation channel are involved in the mechanotransduction course when osteoblasts respond to the mechanical stimulation.
Related Concept Videos
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...
Osteoclasts in Bone Remodeling
Tension Response at Adherens Junctions
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...
Bone Remodeling
Mechanically-gated Ion Channels
The Bone Matrix
