Related Experiment Video

Updated: Aug 18, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Subacute sclerosing panencephalitis (SSPE) associated with congenital measles infection

Enver Simşek1, Ayhan Oztürk, Cevdet Yavuz

  • 1Department of Pediatrics, Abant Izzet Baysal University, Düzce Faculty of Medicine, Düzce, Turkey.

The Turkish Journal of Pediatrics
|May 12, 2005
PubMed

Insights

This case report details a rare instance of subacute sclerosing panencephalitis (SSPE) in a 13-month-old, linked to congenital measles infection in the infant. The diagnosis was confirmed through clinical signs, EEG, CSF analysis, and MRI findings.

Area of Science:

  • Neurology
  • Pediatrics
  • Infectious Diseases

Background:

  • Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurological disorder.
  • Congenital measles infection is an uncommon cause of SSPE, with few documented cases.
  • Early diagnosis and understanding of SSPE are crucial for managing affected children.

Observation:

  • A 13-month-old male infant presented with recurrent myoclonic jerks.
  • The infant's mother had measles during pregnancy, and the infant had elevated measles antibody titers.
  • Neurological examination revealed characteristic EEG abnormalities and MRI showed white matter lesions.

Findings:

  • The patient was diagnosed with SSPE based on clinical presentation, electroencephalography (EEG), cerebrospinal fluid (CSF) analysis, and brain MRI.
  • CSF analysis revealed an oligoclonal IgG band, indicative of an intrathecal immune response.
  • MRI findings demonstrated high signal intensity lesions in the subcortical white matter.

Implications:

  • This case highlights the importance of considering congenital measles as a potential cause of SSPE.
  • The findings contribute to the limited literature on SSPE associated with congenital measles.
  • Further research is needed to understand the pathogenesis and long-term outcomes of SSPE in congenital measles cases.

More Related Videos

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Mouse Models of Periventricular Leukomalacia06:24

Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

Related Concept Videos

Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...