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Growth and nutrition of children with chronic renal failure
1Head of Nephrology, P. & A. Kyriakou Children's Hospital, Athens, Greece.
Insights
Growth delay is a significant challenge for children with chronic renal failure (CRF). Optimal management of associated conditions is crucial before initiating growth hormone therapy for better outcomes.
Area of Science:
- Pediatric Nephrology
- Endocrinology
- Growth and Development
Background:
- Chronic renal failure (CRF) in children is strongly linked to significant growth delays.
- Growth retardation impedes the complete rehabilitation and final adult height of affected children.
- Factors like late referral and suboptimal care contribute to growth issues in pediatric CRF.
Purpose of the Study:
- To highlight the persistent challenge of growth retardation in pediatric CRF.
- To emphasize the importance of comprehensive management of CRF complications.
- To underscore the prerequisite of optimizing medical care before growth hormone therapy.
Main Methods:
- Review of existing evidence on growth in pediatric CRF.
- Analysis of factors contributing to growth failure.
- Discussion of optimal management strategies for CRF in children.
Main Results:
- Growth retardation remains a primary obstacle in pediatric CRF rehabilitation.
- Suboptimal clinical care and late referrals are identified as key contributors.
- Effective management of malnutrition, renal osteodystrophy, acidosis, salt wasting, and anemia is essential.
Conclusions:
- Addressing growth delay in pediatric CRF requires a multifaceted approach.
- Optimizing the management of underlying medical conditions is paramount.
- Growth hormone therapy should be considered only after comprehensive care optimization.
Abstract:
It has long been recognized that chronic renal failure (CRF) in children is associated with growth delay. Still In our days nevertheless, growth retardation remains today a major impediment to the full rehabilitation of children with CRF. The reduction of in height velocity frequently results in diminished final adult height. Available evidence suggests that growth retardation might be the result of late referral and/or suboptimal clinical care in children with CRF. Management of malnutrition, renal osteodystrophy, metabolic acidosis, salt wasting and anemia should be optimal before recombinant human growth hormone initiation.
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