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Hypoxia inducible factor pathways as targets for functional foods
1Food Protein Biotechnology Laboratory, Department of Food Science, Louisiana State University Agricultural Center, 111 Food Science Building, Baton Rouge, Louisiana 70803, USA. jlosso@agctr.lsu.edu
Journal of Agricultural and Food Chemistry
|May 12, 2005
Summary
Chronic angiogenic diseases involve hypoxic cells that promote tumor growth and treatment resistance. Functional foods may target hypoxia-inducible factor (HIF) pathways to inhibit angiogenesis and prevent disease.
Area of Science:
- Biochemistry
- Molecular Biology
- Pathology
Background:
- Chronic angiogenic diseases like cancer and atherosclerosis involve hypoxic cells, characterized by anaerobic metabolism and resistance to treatment.
- Hypoxia-inducible factor (HIF), a heterodimer of HIF-1alpha and HIF-1beta, is crucial for cellular adaptation to low oxygen conditions.
- Activated HIF promotes angiogenesis, vascular remodeling, and inflammation, contributing to disease progression and therapeutic failure.
Purpose of the Study:
- To review the role of hypoxia and HIF-1alpha in chronic angiogenic diseases.
- To explore the potential of functional foods in targeting HIF-1alpha pathways for therapeutic benefit.
Main Methods:
- Literature review summarizing experimental and clinical evidence on hypoxia in angiogenic diseases.
- Discussion of dietary compounds that modulate HIF-1alpha activity.
Main Results:
- Hypoxic cells are aggressive and contribute to treatment resistance in angiogenic diseases.
- HIF-1alpha activation under hypoxia drives proangiogenic gene expression.
- Certain dietary compounds (quinones, phenolics, vitamins, etc.) can down-regulate HIF-1 pathways.
Conclusions:
- Hypoxia plays a critical role in the pathogenesis of chronic angiogenic diseases.
- Targeting HIF-1alpha pathways offers a potential therapeutic strategy.
- Functional foods may provide a natural and effective approach to inhibit hypoxia-induced angiogenesis and prevent disease.