Non-thrombogenicity by novel surface modification methods

Three novel methods, recently developed by us, for the synthesis of non-thrombogenetic materials were reviewed. The first was the utilization of poly(vinyl sulfonate) as a heparinoid and a newly synthesized polymerizable-thrombin-inhibitor. The chemicals were grafted onto the surfaces of materials. The second was the use of thrombin-substrate-analog peptide. The immobilized peptide was decomposed by blood coagulation factors and inhibited thrombus formation on the surface. The third method was the enhancement of endothelialization by immobilization of bio-signal molecules. The immobilized biosignals remarkably accelerated the growth of endothelial cells.