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Related Experiment Videos

Extra temporal involvement in herpes simplex encephalitis.

M Wasay1, S F Mekan, B Khelaeni

  • 1Department of Medicine and Neurology, The Aga Khan University, Karachi, Pakistan. mohammad.wasay@aku.edu

European Journal of Neurology
|May 12, 2005
PubMed
Summary
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Herpes simplex encephalitis (HSE) often shows temporal lobe abnormalities. However, extra-temporal involvement is common in HSE, sometimes being the only abnormality found on brain imaging.

Area of Science:

  • Neurology
  • Radiology
  • Infectious Diseases

Background:

  • Herpes simplex encephalitis (HSE) is typically associated with temporal lobe abnormalities on neuroimaging.
  • Extra-temporal involvement in HSE is less frequently described but may be significant.

Purpose of the Study:

  • To investigate the frequency and pattern of extra-temporal involvement in patients diagnosed with HSE.
  • To determine if extra-temporal abnormalities can be the sole imaging finding in HSE.

Main Methods:

  • Retrospective review of neuroimaging (CT/MRI) in 20 patients diagnosed with HSE.
  • Analysis of the location and extent of brain abnormalities, focusing on temporal versus extra-temporal regions.

Main Results:

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  • Extra-temporal involvement was observed in 11 (55%) of the 20 HSE patients.
  • Three patients (15%) presented with pure extra-temporal abnormalities.
  • Temporal lobe involvement was seen in 12 (60%) patients, with four (20%) showing pure temporal lobe involvement.

    • Conclusions:

    • Extra-temporal brain abnormalities are a common finding in herpes simplex encephalitis.
    • In a notable proportion of HSE cases, extra-temporal involvement may be the exclusive neuroimaging abnormality.