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Updated: Aug 18, 2026

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
Published on: October 14, 2021
Treatment of motor dysfunction in Parkinson's disease: an overview
Stéphane Thobois1, Florence Delamarre-Damier, Pascal Derkinderen
1Service de Neurologie, Hôpital Neurologique Pierre Wertheimer, Lyon, France.
Abstract:
Levodopa remains the most effective treatment for Parkinson's disease (PD). However, the use of this drug is complicated by several adverse effects, in particular motor fluctuations and dyskinesias. Drugs providing more continuous dopaminergic stimulation and surgical approaches, such as deep-brain stimulation, have an important ameliorative effect on these problems. Despite these advances, the progression of the disease remains unaffected and strategies that slow or stop the neurodegenerative process are currently not available. Nevertheless, several compounds or surgical procedures are candidates for being neuroprotective and some of them are under evaluation.
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