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Updated: Jul 30, 2026

Primary Culture of Mouse Dopaminergic Neurons
Published on: September 8, 2014
Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors
1Basal Gang, Laboratoire de Physiologie et Physiopathologie de la Signalisation Cellulaire, CNRS UMR 5543, Université Victor Segalen-Bordeaux 2, France.
Abstract:
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Taking advantage of a monkey brain bank constituted to study the pathophysiology of levodopa-induced dyskinesia, we here report the changes affecting D1, D2 and D3 dopamine receptors within the striatum of four experimental groups of non-human primates: normal, parkinsonian, parkinsonian treated with levodopa without or with dyskinesia. We also report the possible role of arrestin and G protein-coupled receptor kinases.
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