Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Normal N400 in mood disorders.

Patricia Deldin1, Jennifer Keller, Brooks R Casas

  • 1University of Michigan, 525 E University, 2252 East Hall, Ann Arbor, MI 48109, USA. pjdeldin@umich.edu

Biological Psychology
|May 12, 2005
PubMed
Summary

Major depression and dysthymia do not appear to involve language processing abnormalities. Brain responses to sentence endings were similar in individuals with mood disorders and controls, suggesting intact semantic processing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Fetal Gene Regulatory Gene Deletions With Poor Cognition in Schizophrenia and Community-Based Samples.

The American journal of psychiatry·2026
Same author

Low-Dose Buprenorphine Following Ketamine Treatment for Suicidal Ideation in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.

The American journal of psychiatry·2026
Same author

NCCN Guidelines® Insights: Distress Management, Version 1.2026.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Pilot Implementation of a National, Web-Based Abortion Curriculum for Obstetrics-Gynecology Residents.

O&G open·2026
Same author

Resting-state periodic and aperiodic brain oscillations from birth to preschool years: Aperiodic maturity predicts developmental course.

Developmental cognitive neuroscience·2026
Same author

Functional cycling ergometry with or without electrical stimulation in individuals with secondary progressive multiple sclerosis: A randomized controlled trial.

Multiple sclerosis and related disorders·2026

Area of Science:

  • Cognitive Neuroscience
  • Clinical Psychology
  • Psycholinguistics

Background:

  • Major depression is often associated with cognitive deficits.
  • However, consistent language processing abnormalities in depression remain unclear.
  • Previous research has yielded mixed results regarding semantic processing in mood disorders.

Purpose of the Study:

  • To investigate whether individuals with major depression or dysthymia exhibit abnormal semantic processing.
  • To examine event-related brain potentials (N400 amplitudes) during sentence processing in mood-disordered populations.
  • To determine if semantic processing deficits are a generalized feature of depression.

Main Methods:

  • Utilized an event-related potential (ERP) paradigm measuring N400 amplitudes.

Related Experiment Videos

  • Participants passively viewed sentences with congruent or incongruent endings.
  • Compared N400 amplitudes between individuals with major depression (N=50), dysthymia (N=14), and healthy controls (N=41).

    • Main Results:

    • Individuals with major depression and dysthymia showed N400 amplitudes comparable to controls.
    • No significant differences in N400 responses were observed across the groups.
    • This suggests intact semantic processing in the context of this sentence comprehension task.

    Conclusions:

    • The findings indicate that major depression and dysthymia are not consistently associated with semantic processing abnormalities.
    • Results support behavioral studies suggesting intact semantic processing in depression.
    • Abnormalities in controlled processing in some tasks may not stem from a generalized semantic deficit.