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Updated: Aug 18, 2026

Isolation and Activation of Murine Lymphocytes
Published on: October 30, 2016
Marginal zone B cells in lymphocyte activation and regulation
Thiago Lopes-Carvalho1, Jeremy Foote, John F Kearney
1Department of Microbiology, University of Alabama at Birmingham, Alabama 35294, USA.
Abstract:
Marginal zone (MZ) B cells, together with other strategically located innate cells, constitute the first line of defense against blood-borne microorganisms, viruses and toxins in the spleen. Their fast and efficient protective antibody responses are well characterized; however, much less is known of their interactions with other cell types during immune responses. Recent work has demonstrated that MZ B cells can directly activate T cells; and MZ B cells also interact with other antigen presenting cells, transporting and concentrating antigen during the course of T-dependent and T-independent immune responses.
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