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Updated: Aug 18, 2026

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes
Published on: May 14, 2012
Notch: control of lymphocyte differentiation in the periphery
Margaret J Dallman1, Emma Smith, Robert A Benson
1Section of Immunology and Infection, Department of Biological Sciences, Imperial College, London, UK. m.dallman@imperial.ac.uk
Abstract:
The complexity of the Notch signalling pathway has impeded progress in understanding its precise role in differentiation processes of the mature peripheral immune system. Nevertheless, both B and T lymphocyte responses are undoubtedly influenced by Notch ligation, and defining the mechanisms by which this is achieved remains a challenge. How the innate-adaptive interface and interactions between lymphocytes can be affected, together with the potential of this pathway for therapeutic intervention remain important and stimulating issues.
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