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Understanding the generation and function of memory T cell subsets

Antonio Lanzavecchia1, Federica Sallusto

  • 1Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland. lanzavecchia@irb.unisi.ch

Current Opinion in Immunology
|May 12, 2005
PubMed

Memory T cells can be broadly divided into central memory and effector memory subsets, which are endowed with different capacities to home to lymphoid or non-lymphoid tissues, to proliferate in response to antigen or cytokines and to perform effector functions. In the past few years progress has been made in understanding the properties of these memory T cell subsets and, in particular, the signals required for their generation and maintenance. Collectively these data point to a critical role of central memory T cells in conferring long-term immunity.

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