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Related Experiment Videos

Tissue transglutaminase at embryo-maternal interface.

Maryam Kabir-Salmani1, Shigetatsu Shiokawa, Yoshihiro Akimoto

  • 1Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Shinkawa 6-20-2, Mitaka, Tokyo 181-8611, Japan. kabirs_m@yahoo.com

The Journal of Clinical Endocrinology and Metabolism
|May 12, 2005
PubMed
Summary

Tissue transglutaminase (tTG) is crucial for embryo implantation, mediating placental cell adhesion to fibronectin (FN) via integrin signaling pathways at the embryo-maternal interface.

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Area of Science:

  • Reproductive biology
  • Cellular and molecular biology
  • Biochemistry

Background:

  • Tissue transglutaminase (tTG) binds fibronectin (FN) and acts as a coreceptor for beta1 and beta3 integrins.
  • FN and integrins play vital roles in embryo implantation.

Purpose of the Study:

  • To investigate the expression pattern of tTG.
  • To determine the physiological function of tTG at the embryo-maternal interface.

Main Methods:

  • Primary cultures of human first-trimester placentas and endometrial biopsies.
  • Trophoblastic cell lines.
  • Electron microscopy, immunostaining, western blotting, and function assays.

Main Results:

  • tTG was expressed on uterine pinopodes and extravillous trophoblast lamellipodia.

Related Experiment Videos

  • tTG colocalized with beta1 and beta3 integrins and interacted with alpha(v)beta3 integrin.
  • tTG mediated placental cell adhesion and spreading on FN and FN fragments.

    • Conclusions:

    • tTG is actively involved in embryo-maternal interface adhesion.
    • tTG interacts with FN and activates integrin-signaling pathways.
    • tTG plays a significant role in early pregnancy events.