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Astrocytic edema in CNS trauma
1Division of Neurosurgery, Albany Medical College, New York.
Journal of Neurotrauma
|March 1, 1992
Summary
Astrocytic swelling, a rapid response to central nervous system (CNS) trauma, can be detrimental. Pharmacologic inhibition of this swelling may offer therapeutic benefits for head trauma injuries.
Area of Science:
- Neuroscience
- Cellular Biology
- Pathology
Background:
- Astrocytic swelling is a rapid cellular response to central nervous system (CNS) trauma.
- This swelling precedes the reactive astrogliosis typically observed following neuronal and axonal injury.
- It is considered a pathological exaggeration of normal astrocytic functions, including ion and pH regulation.
Purpose of the Study:
- To review the occurrence and implications of astrocytic swelling following CNS trauma.
- To discuss the potential negative consequences of astrocytic swelling on brain function.
- To explore possible pharmacologic interventions for mitigating swelling-related damage.
Main Methods:
- Literature review of astrocytic swelling in response to CNS trauma.
- Analysis of the pathophysiological mechanisms underlying astrocytic swelling.
- Evaluation of potential therapeutic strategies, including pharmacologic agents.
Main Results:
- Astrocytic swelling is an early and rapid event post-CNS trauma.
- Swelling can disrupt ion homeostasis, neurotransmitter uptake, and contribute to excitotoxicity.
- An anion transport inhibitor, L-644,711, shows potential in preventing deleterious effects.
Conclusions:
- Astrocytic swelling is a critical early event in CNS injury.
- Understanding its pathological role is key to developing neuroprotective strategies.
- Pharmacological inhibition of astrocytic swelling may be a viable therapeutic approach for head trauma.