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Updated: Aug 18, 2026
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
[The expression of Fas and bcl-2 in hamster buccal carcinogenesis]
Xia Wang1, Shan-zhen Sun, Xiao-ying Zhang
1Department of Oral Pathology, School of Stomatology, Shandong University, Shandong Province, China.
Purpose:
To study the expression of Fas and bcl-2 in oral carcinogenesis.
Methods:
Using immunohistochemical method,we studied the expression of Fas and bcl-2 in DMBA induced hamster baccal carcinogenesis including negative control (14), hyperkeratosis (7), epithelial dysplasia (mild 12, moderate 7, severe 9), oral squamous cell carcinoma(OSCC) (25). Non-parametric test was used for statistical analysis.
Results:
Fas was expressed in negative control consistently except stratum basale,and there was down-regulation in oral dysplasia and OSCC (chi(2)=45.576, P<0.05).bcl-2 was rarely expressed in negative control, and there was up-regulation in oral dysplasia and OSCC (chi(2)=19.433, P<0.05).
Conclusions:
Fas and bcl-2 may play an important role in inhibiting apoptosis coordinately, resulting in the imbalance of cell proliferation and apoptosis, which may contribute to oral carcinogenesis.
