Protein sequence tags: a novel solution for comparative proteomics
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Updated: Aug 18, 2026

TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis
Published on: June 8, 2020
Karsten Kuhn1, Thorsten Prinz, Jürgen Schäfer
1Proteome Sciences R&D, Frankfurt am Main, Germany.
Abstract:
Comparative proteome profiling using stable isotope peptide labelling and mass spectrometry has emerged as a promising strategy. Here, we show the broad potential of our proprietary protein sequence tag (PST) technology. A special feature of PST is its ability to detect a wide variety of proteins including the pharmaceutically relevant membrane and nuclear proteins. This procedure addresses a similar number of proteins, compared to the multidimensional protein identification technology approach, but offers additionally a quantitative analysis with its recently developed quantitative PST version.
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